In vitro inhibitory potential of avocado fruits, Persea americana (Lauraceae) against oxidation, inflammation and key enzymes linked to skin diseases

Avocado (Persea americana Mill.) is a member of Lauraceae with one-seeded berry fruit and cultivated in all tropical, subtropical regions the world Southern coast region Turkey. Oxidative damage caused by UV can trigger inflammation, resulting serious inflammatory skin diseases including eczema, seborrheic dermatitis, hyperpigmentation ageing. Enzyme inhibitors involved melanogenesis, such as tyrosinase, have been used recently for cosmetic products. Objective: This study aimed to evaluate antioxidant, anti-inflammatory, anti-tyrosinase activities total polyphenolic contents different parts P. fruit. Methods: The was divided into exocarp, mesocarp, seed, then methanol n-hexane extracts were prepared. DPPH ABTS free radical scavenging capacities inhibitory potentials on lipid peroxidation determined investigate antioxidant extracts. Anti-inflammatory evaluated measuring stabilization level human red blood cell membrane. tyrosinase samples using mushroom tyrosinase. Results: In general possessed remarkable higher than highest activity seed (4.17 ± 0.04 mg/mL) followed exocarp (5.25 0.05 mg/mL). Overall greatest obtained (0.03 0.01 anti-lipid assay, noticed (7.71 0.36 µg/mL) (12.12 0.34 µg/mL), while inactive. exhibited anti-inflammatory properties However, maximum (0.40 (0.46 Conclusions: These are promising candidates use natural products-based inflammation-related disease, also dermatological applications.